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-Discontinuation due to adverse events: 4.1% (4 mg) vs 11.3% (12 mg) vs 4.9% placebo -Dysesthesia reported in 12.5% at 12 mg vs 0.9% placebo Open questions: -The 4 mg dose gave nearly 20% weight loss with a single dose escalation step and a discontinuation rate indistinguishable from placebo
The total number of primary component MACE endpoints was 254 (108 [6.6%] with semaglutide and 146 [8.9%] with placebo)
It is also possible that any or all of the effects observed in this study could vary throughout the anatomy of the dentate gyrus (dorsal vs ventral, inferior vs superior blades of the subgranular zone)
If you must inject during travel, use an alcohol wipe on the injection site, use a standard injection site you are comfortable with, and dispose of the needle in your sharps container immediately
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